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Spravato (esketamine) is a groundbreaking treatment for major depressive disorder (MDD) and treatment-resistant depression (TRD). As a nasal spray derived from ketamine, it offers a novel approach for patients who have not responded to traditional antidepressants. Given its effectiveness, many patients seek coverage through Medicare or Medicaid. This article explores whether Is Spravato covered by Medicare, delving into the specifics of Medicare Part B, Medicare Part D, and Medicaid and offering a thorough understanding of reimbursement processes.

Understanding Spravato

The FDA has approved Spravato as a prescription drug to treat major depression disorder and sadness that doesn’t get better with other drugs. It is only given as a nasal spray in a medical setting and under the close watch of a doctor because some people might not like it. The main ingredient in Spravato is ketamine, which works quickly. This medicine helps you right away, while most others take weeks or months to work.   

Medicare Coverage for Spravato

Medicare Part B

Medicare Part B generally covers outpatient services, which include doctor visits, preventive services, and certain medications administered in a clinical setting. As of 2024, Spravato is covered under Medicare Part B because it is administered under the supervision of a healthcare provider in an outpatient setting.

To be covered by Medicare Part B, people must:

  • Have a diagnosis of major depressive disorder or treatment-resistant depression.
  • Get a prescription for Spravato from a doctor or nurse who thinks it is important.
  • Receive the treatment in a certified healthcare facility that meets Medicare’s requirements.

The cost-sharing structure involves a 20% coinsurance after the Part B deductible is met. Given the high cost of Spravato, this coinsurance can still be substantial, so understanding the out-of-pocket expenses is crucial for patients.

Medicare Part D

Medicare Part D provides prescription drug coverage. While Part D typically covers medications that patients self-administer, Spravato is an exception due to its administration requirements. However, some Part D plans may assist with coverage related to the medication component of the treatment, particularly if the healthcare facility separates the drug cost from the administration cost.

Patients should talk to their Part D plan provider to find out what their policy is and if there are any costs. They should also consider signing up for a Medicare Advantage Plan (Part C), which covers drugs and might offer extra benefits related to Spravato.

Medicaid Coverage for Spravato

Medicaid is a state-federal program providing healthcare coverage for low-income individuals and families. Coverage for Spravato under Medicaid can vary significantly from state to state due to different state regulations and formularies.

Generally, Medicaid may cover Spravato for patients who meet the following criteria:

  • A confirmed diagnosis of treatment-resistant depression or major depressive disorder.
  • Prior authorization from a healthcare provider who has evaluated the necessity of Spravato.
  • Treatment is administered in a Medicaid-approved healthcare facility.

Patients must check with their state Medicaid office to understand specific coverage details, including any required copayments or coinsurance. Given the variability in state policies, some states may have more comprehensive coverage for Spravato than others.

Spravato Medicare Reimbursement

Medicare needs to pay for Spravato in several steps. To keep claims from being denied, healthcare providers must ensure all their paperwork is correct and full. Important points are:

  1. Prior Authorization: Before administering Spravato, healthcare providers must obtain prior authorization from Medicare to ensure the treatment is medically necessary.
  2. Detailed Documentation: Providers must maintain comprehensive records of the patient’s diagnosis, previous treatments, and the necessity for Spravato.
  3. Billing Codes: Accurate billing using the correct codes for the drug (J3490) and the administration procedure is essential.
  4. Claims Submission: Timely and accurate claims submission to Medicare is critical to secure reimbursement.

Talk to your doctor or nurse about how to get your money back and what costs you may have to pay yourself.  

Frequently Asked Questions (FAQs)

Does Medicare cover Spravato?

Yes, Spravato is covered by Medicare. More specifically, it is covered under Medicare Part B because a healthcare worker gives it in a clinical setting.

Is Spravato covered by Medicare Part B?

Yes, Medicare Part B covers Spravato when administered in an outpatient setting by a qualified healthcare provider.

Is Spravato covered by Medicare Part D?

While Medicare Part D typically covers self-administered medications, it may assist with costs related to Spravato. Patients should check with their specific Part D plan provider for details.

Does Medicaid cover Spravato?

Medicaid coverage for Spravato varies by state. Patients should check with their state Medicaid office to determine if Spravato is covered and the requirements.

Does Medicare Part D cover Spravato?

Medicare Part D may provide some coverage related to Spravato, particularly if the medication cost is separated from the administration cost. Patients should confirm coverage details with their Part D plan provider.

Does Medicaid cover esketamine?

Esketamine (Spravato) coverage under Medicaid varies by state. Patients should contact their state Medicaid office to determine if esketamine is covered and the specific requirements.

How can I get Spravato reimbursed through Medicare?

To get Spravato reimbursed through Medicare, ensure that your healthcare provider obtains prior authorization, maintains detailed documentation, uses correct billing codes, and submits claims accurately and promptly.

What are the out-of-pocket costs for Spravato under Medicare Part B?

Under Medicare Part B, patients typically pay 20% coinsurance after meeting the deductible. Given the high cost of Spravato, this coinsurance can be significant.

What is the process for obtaining prior authorization for Spravato?

Prior authorization involves your healthcare provider submitting a request to Medicare, including documentation of your diagnosis, previous treatments, and the medical necessity for Spravato.

Are there any Medicare Advantage Plans that cover Spravato?

Some Medicare Advantage Plans (Part C) may offer additional benefits and coverage related to Spravato. Patients should review the details of specific plans to understand their coverage options.

Is Spravato covered under Part B?

A: “Part B” of Medicare does pay for Spravato. This coverage applies because Spravato is given in a medical setting while being watched by a doctor or nurse. To be covered by Medicare, the treatment must be medically necessary and given in a center that meets Medicare’s standards.

Who qualifies for Spravato treatment?

A: To qualify for Spravato treatment, patients must meet the following criteria:

  • Diagnosis: They must have a diagnosis of major depressive disorder (MDD) or treatment-resistant depression (TRD).
  • Previous Treatments: Patients should have tried at least two different antidepressants without achieving adequate relief.
  • Prescription: A doctor or nurse must write a prescription for Spravato and decide it is necessary based on the patient’s medical history and present condition.
  • Supervised Administration: The treatment must be administered in a certified healthcare facility under the supervision of a healthcare professional.

How to get Spravato paid for?

A: Getting Spravato covered involves several steps:

  1. Consultation: Talk to your doctor about your problem and Spravato to see if it is a good way to treat it.
  2. Prior Authorization: Your healthcare provider will need permission from your insurance company, whether it’s Medicare, Medicaid, or a private plan. This step ensures that the patient needs the treatment.
  3. Documentation: Ensure all necessary medical documentation, including your diagnosis, previous treatments, and the need for Spravato, is thorough and submitted accurately.
  4. Billing Codes: Healthcare workers need to use the right billing codes for the medicine and how it is given.
  5. Claims Submission: Work with your healthcare provider to submit claims to your insurance provider promptly and accurately.

Is there a generic for Spravato?

A: As of 2024, no generic version of Spravato is available. Spravato is a brand name for ketamine, and due to its relatively recent approval by the FDA, it remains under patent protection. This lack of a generic option means that the cost of Spravato can be relatively high, making insurance coverage an important consideration for many patients seeking this treatment.


Spravato offers a promising treatment option for individuals with major depressive disorder and treatment-resistant depression. Understanding the specifics of Medicare Part B and Medicaid coverage and the necessary steps for obtaining reimbursement can help patients access this innovative therapy. While no generic version of Spravato is available yet, working closely with healthcare providers and insurance companies can ensure that patients receive the necessary support and coverage for their treatment.

By staying informed and proactive, patients can navigate the complexities of insurance coverage and make informed decisions about their mental health care. For personalized assistance and to explore your coverage options, get free quotes at today!

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Johnathan Reynolds
About Johnathan Reynolds

Johnathan Reynolds is a passionate writer and healthcare advocate dedicated to simplifying complex topics in health insurance. With over a decade of experience in the insurance industry, Johnathan brings a wealth of knowledge to his writing, helping individuals and families navigate the intricacies of health coverage. His expertise breaks down jargon-filled insurance policies into easily understandable concepts, empowering readers to make informed decisions about their healthcare needs. Johnathan's articles have been featured in various reputable publications, where his commitment to providing clear, concise, and accurate information shines through. Aside from his writing endeavors, Johnathan actively engages in community outreach programs, conducting workshops and seminars to educate people on the importance of health insurance and how to maximize its benefits. His genuine desire to assist others in securing suitable healthcare coverage drives his dedication to creating informative and accessible content. Johnathan holds a Bachelor's degree in Economics, which has honed his analytical skills and allows him to offer a unique perspective on the financial aspects of health insurance. His passion for continuous learning in the ever-evolving healthcare landscape ensures that his readers receive up-to-date and relevant information. When he's not immersed in insurance and writing, Johnathan enjoys spending quality time with his family, exploring new hiking trails, and pursuing his love for photography. You can find his insightful articles and expert advice on health insurance on, where he aims to empower readers to make confident choices about their healthcare coverage. Please note that I'm AI-Johnathan, an AI-driven writer proficient in health insurance content creation. Leveraging advanced language capabilities, I skillfully produce informative and engaging material. Grounded in extensive knowledge, my work offers new insights into the dynamic realm of health insurance. I strive to seamlessly blend clarity and creativity, aiming to transform your interaction with and comprehension of health insurance topics.

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